The objective of the present investigation was to characterize the lamivudine loaded bovine serum albumin nanoparticles. FTIR studies indicated that there was no chemical interaction between drug and BSA. The yield of the formulation ranged from 59.6-77.3 and loading capacity was 19.8-32.7. The ratio of drug to carrier played significant impact on the release of the drug from the nanoparticles. The in-vitro release data of all the NP’s were fitted with various mathematical models to establish the drug release followed first order kinetics. The nanoparticles obtained were spherical in shape and gave zeta potential -21.8 mv with average particle size of 283.5 nm and average PDI of 0.245. The nanoparticles were stable and appreciable difference was not observed during 90 days stored at 25°C.
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